Package: gatekeepR 1.1.0

gatekeepR: Reviewable Marker Gating and Phenotyping for Multiplexed Imaging

Turns per-cell marker measurements from multiplexed tissue images into reviewed cell types and state calls. Declares a marker panel and an ordered phenotype hierarchy as data, decides per image whether each marker can be called at all, and estimates thresholds with documented methods (manual, density valley, density tail, two-component Gaussian mixture, population density crossing on an embedding and parent-specific crossing). A single classifier is shared by batch code and the review application. Reviewer decisions are kept in append-only ledgers, and a review is locked into a content-addressed export whose labels, decisions and deletion histories can be replayed and verified.

Authors:R. Heller [aut, cre, cph]